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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

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Therapeutic Massage for Psychological Well-being in Geriatric Oncology
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Psychiatric disorders in the elderly.

Ingmar Skoog1

  • 1Institute of Neuroscience and Physiology, Section for Psychiatry Section, Unit of Neuropsychiatric Epidemiology, University of Gothenburg, Sweden. Ingmar.Skoog@neuro.gu.se

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|August 13, 2011
PubMed
Summary
This summary is machine-generated.

Psychiatric disorders like depression, anxiety, and psychosis are common in older adults, even without dementia. These conditions impact quality of life and cognitive function, highlighting the need for better understanding and care in elderly populations.

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Published on: December 18, 2016

Area of Science:

  • Geriatric Psychiatry
  • Neuroscience
  • Public Health

Background:

  • Psychiatric disorders, including depression, anxiety, and psychosis, are increasingly recognized in elderly populations.
  • The age-related prevalence and clinical presentation of these disorders in non-demented elderly individuals require further investigation.
  • Comorbidity with other psychiatric and somatic disorders is substantial in this demographic.

Purpose of the Study:

  • To investigate the prevalence and characteristics of depression, anxiety disorders, and psychosis in elderly individuals without dementia.
  • To explore the relationship between these psychiatric disorders and cognitive function, including their potential as risk factors for dementia.
  • To identify underlying neurobiological and psychosocial factors contributing to psychiatric disorders in old age.

Main Methods:

  • Review of recent research on psychiatric disorders in elderly populations.
  • Analysis of clinical expressions and symptom severity in older adults compared to younger individuals.
  • Examination of comorbidity patterns between psychiatric and somatic disorders.
  • Assessment of the association between psychiatric disorders and cognitive decline.

Main Results:

  • Depression, anxiety disorders, and psychosis are more prevalent in the elderly than previously thought.
  • Clinical presentation in old age may involve milder and less pronounced symptoms.
  • Significant comorbidity exists between psychiatric disorders and with somatic conditions.
  • Cognitive impairment is frequently observed in elderly individuals with these psychiatric conditions.

Conclusions:

  • Psychiatric disorders are a significant concern in the elderly, impacting quality of life and cognitive health.
  • Cerebral neurodegeneration and cerebrovascular disease are implicated, alongside psychosocial factors.
  • These disorders carry serious consequences, including disability, increased mortality, and social deprivation.