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Updated: May 30, 2026

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
Published on: October 15, 2019
Interkinetic nuclear migration: reciprocal activities of dynein and kinesin
Sofya Kulikova1, Marios Abatis, Celine Heng
1Joint Master in Neuroscience; University of Strasbourg-France; Strasbourg, France.
Abstract:
A hallmark of neurogenesis in vertebrate is the apical-basal fluctuation of radial glia nuclei. Such a phenomenon, called INM, has been known for decades and is closely associated with mitosis but still puzzles scientists. An impressive step in the molecular understanding of INM has recently been achieved by Tsai and coworkers. Using RNA interference associated with time-lapse imaging, these authors demonstrated a dual motor system that can push/pull the nuclei accordingly with the cell cycle stages.
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