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Protein C deficiency in liver disease
1American Red Cross Blood Services, Farmington, CT.
Annals of Clinical and Laboratory Science
|March 1, 1990
Summary
Protein C, a liver-synthesized plasma protein, plays a role in blood coagulation. Low protein C levels indicate abnormal liver function and can predict liver transplant success.
Area of Science:
- Biochemistry
- Hematology
- Hepatology
Background:
- Protein C is a vitamin K-dependent serine protease zymogen in plasma.
- Activated protein C inhibits coagulation and promotes fibrinolysis.
- Protein C synthesis in the liver involves complex post-translational modifications.
Purpose of the Study:
- To explore the relationship between protein C levels and liver function.
- To assess the utility of protein C levels as an indicator of liver transplantation outcomes.
Main Methods:
- Analysis of protein C synthesis and its dependence on liver function.
- Observation of protein C levels in relation to oral anticoagulant therapy.
- Evaluation of protein C levels in liver transplant recipients.
Main Results:
- Protein C synthesis is sensitive to liver function, with levels falling rapidly under altered synthesis conditions.
- Low protein C levels are highly indicative of abnormal liver function.
- Successful liver transplantation can correct homozygous protein C deficiency.
- Plasma protein C levels may serve as a predictive indicator for liver transplant success.
Conclusions:
- Protein C levels are a sensitive marker for liver function and disease.
- Monitoring protein C levels can aid in assessing liver health and transplant outcomes.