Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet abnormalities in hepatobiliary diseases.

A B Glassman1

  • 1National Reference Laboratory, Nashville, TN 37217.

Annals of Clinical and Laboratory Science
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2001
Same author

Detection of trisomy 8 in philadelphia chromosome-positive CML patients using conventional cytogenetic and interphase fluorescence in situ hybridization techniques and its relation to c-myc involvement.

Annals of clinical and laboratory science·2001
Same author

A unique, complex variant philadelphia chromosome translocation in a patient with typical chronic myelogenous leukemia.

Archives of pathology & laboratory medicine·2001
Same author

Detection of chromosome 11q13 breakpoints by interphase fluorescence in situ hybridization. A useful ancillary method for the diagnosis of mantle cell lymphoma.

American journal of clinical pathology·2000
Same author

Numeric chromosomal abnormalities in small lymphocytic and transformed large cell lymphomas detected by fluorescence in situ hybridization of fine-needle aspiration biopsies.

Cancer·2000
Same author

Early detection of relapse by hypermetaphase fluorescence in situ hybridization after allogeneic bone marrow transplantation for chronic myeloid leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2000
Same journal

<i>Letter to the Editor:</i> Detection of <i>Chlamydia trachomatis</i> Immunoglobulin E Antibody in Human Sera.

Annals of clinical and laboratory science·2026
Same journal

Comparison of the DNA Preservation Capacity of Two Methods for the Long-Term Cryopreservation of Whole Blood Samples.

Annals of clinical and laboratory science·2026
Same journal

Recurrence of Primary Mediastinal Yolk Sac Tumor with Brain Metastases: A Case Report and Literature Review.

Annals of clinical and laboratory science·2026
Same journal

Intraoperative Imprint Cytology of <i>SMARCB1</i>-Mutant Desmoplastic Myxoid Tumor of the Pineal Region: A Case Report with Cytologic Differential Diagnosis and Literature Review.

Annals of clinical and laboratory science·2026
Same journal

Bergenin Suppresses Glycolysis and Malignant Progression in Breast Cancer via the IGF1R-MAPK Signaling Pathway.

Annals of clinical and laboratory science·2026
Same journal

Network Pharmacology and <i>in vitro</i> Experimental Validation Reveal the Anticancer Mechanisms of Cichoric Acid in Cervical Cancer.

Annals of clinical and laboratory science·2026
See all related articles

Hepatobiliary diseases can cause platelet count and function abnormalities, including thrombocytosis and thrombocytopenia. These platelet issues are linked to conditions like cirrhosis and hepatitis, impacting patient health.

Area of Science:

  • Hematology
  • Hepatology
  • Pathology

Background:

  • Platelet abnormalities, including altered counts (thrombocytosis, thrombocytopenia) and function (thrombocytopathy, thrombasthenia), are observed in various hepatobiliary diseases.
  • Hepatitis, cirrhosis, portal hypertension, and neoplastic disorders are hepatic conditions frequently associated with these platelet dysfunctions.

Purpose of the Study:

  • To comprehensively examine the spectrum of platelet abnormalities occurring in conjunction with diverse hepatobiliary disorders.
  • To elucidate the specific associations between different liver diseases and their resultant effects on platelet number and function.

Main Methods:

  • Review of existing literature and clinical data on platelet counts and function in patients with hepatobiliary diseases.
  • Categorization of platelet abnormalities (thrombocytosis, thrombocytopenia, thrombocytopathy) based on underlying hepatic conditions.

Related Experiment Videos

Main Results:

  • Thrombocytosis is often a reactive response, notably post-splenectomy.
  • Thrombocytopenia is linked to hypersplenism, dysproteinemias, and liver disease-related disseminated intravascular coagulation (DIC).
  • Qualitative platelet abnormalities (thrombasthenias) are observed in hepatic failure, lipid metabolism disturbances, and medication effects.

Conclusions:

  • Platelet abnormalities are a significant clinical feature of hepatobiliary diseases, ranging from quantitative to qualitative defects.
  • Thrombocytopenia due to portal hypertension and metabolic/therapeutic changes leading to thrombasthenias are particularly common and clinically relevant findings in liver disease.