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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

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Published on: May 13, 2010

Aptamers: selection, modification and application to nervous system diseases.

Y Yang¹, X Ren, H J Schluesener

¹Experimental Medicine Center of Tongji Hospital, Wuhan 430030, People's Republic of China.

Current Medicinal Chemistry

|August 16, 2011

Summary

Aptamers, generated via SELEX, offer high-affinity binding for biomedical applications. Recent modifications enhance their stability and bioavailability, advancing aptamer use in diagnosing and treating nervous system disorders.

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Area of Science:

Biochemistry
Molecular Biology
Biotechnology

Background:

Aptamers are synthetic oligonucleotides produced through Systematic Evolution of Ligands by Exponential enrichment (SELEX).
They exhibit high affinity and specificity for diverse targets due to their unique 3D structures.
Aptamers offer advantages like rapid synthesis, cost-effectiveness, and small size.

Purpose of the Study:

To review recent advancements in aptamer chemical modifications.
To explore the application of modified aptamers in nervous system disorders.
To highlight the potential of aptamers in diagnostics and therapeutics.

Main Methods:

Literature review of aptamer modifications and applications.
Analysis of SELEX process and aptamer characteristics.
Focus on aptamer stability and bioavailability enhancements.

Main Results:

Chemical modifications significantly improve aptamer stability in biological fluids.
Enhanced bioavailability facilitates in vivo applications.
Aptamers show promise for diagnosing and treating neurological conditions.

Conclusions:

Aptamer technology is rapidly evolving with chemical modifications.
Modified aptamers are increasingly viable for therapeutic and diagnostic uses.
Further research into aptamer applications for nervous system disorders is warranted.