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Fructosamine reference ranges in rhesus macaques (Macaca mulatta).

Misty J Williams-Fritze¹, Peter C Smith, Daniel Zelterman

¹The Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. mwilliamsfritze@georgiahealth.edu

Journal of the American Association for Laboratory Animal Science : JAALAS

|August 16, 2011

Summary

This study establishes a reference range for fructosamine in rhesus macaques, aiding in diabetes mellitus diagnosis. The findings highlight higher fructosamine levels in older macaques and males, crucial for veterinary care.

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Area of Science:

Veterinary Medicine
Primate Endocrinology
Comparative Pathology

Background:

Diabetes mellitus (DM) is prevalent in nonhuman primates, impacting both Old and New World species.
Fructosamine testing is vital for assessing recent glycemic control in DM diagnosis and management.
Limited fructosamine reference ranges exist for nonhuman primates, particularly rhesus macaques.

Purpose of the Study:

To establish a reference range for serum fructosamine in rhesus macaques (Macaca mulatta).
To provide a diagnostic tool for evaluating glycemic control in rhesus macaques with suspected or confirmed DM.

Main Methods:

Analysis of serum fructosamine values from a cohort of rhesus macaques.
Statistical comparison of fructosamine levels based on age and sex.

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Main Results:

The established overall reference range for fructosamine in rhesus macaques is 157 to 230 μmol/L.
Significantly higher fructosamine values were observed in male rhesus macaques compared to females.
Older rhesus macaques (≥10 years) exhibited significantly higher fructosamine levels than younger individuals (<10 years).

Conclusions:

The newly established fructosamine reference range offers critical data for diagnosing and managing DM in rhesus macaques.
Age and sex are significant factors influencing fructosamine levels in this species.
This range serves as an essential clinical tool for veterinarians managing primate health.