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Updated: May 30, 2026
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Albumin-based nanoparticles as potential controlled release drug delivery systems
Ahmed O Elzoghby1, Wael M Samy, Nazik A Elgindy
1Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, El-Khartoum Square, Azarita, Alexandria 21521, Egypt. aoelzoghby@yahoo.com
Summary
Albumin nanoparticles are ideal for drug delivery due to their biocompatibility and drug-binding capacity. This review covers their formulation, applications in oncology, and advanced fabrication techniques for targeted delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Albumin is a non-toxic, biocompatible protein ideal for drug delivery systems.
- Albumin nanoparticles offer high drug binding capacity and good tolerability.
- They are extensively investigated for various therapeutic applications, especially in oncology.
Purpose of the Study:
- To provide a comprehensive review of albumin nanoparticles for drug delivery.
- To discuss formulation strategies, fabrication techniques, and in vitro/in vivo outcomes.
- To highlight site-specific drug targeting using albumin nanoparticle modifications.
Main Methods:
- Review of literature on albumin nanoparticle fabrication techniques (e.g., desolvation, nano-spray drying, self-assembly).
- Analysis of in vitro and in vivo studies evaluating albumin nanoparticle efficacy and safety.
- Discussion of surface modification strategies for targeted drug delivery.
Main Results:
- Albumin nanoparticles demonstrate significant potential in drug delivery, particularly in oncology.
- Various formulation and fabrication methods yield nanoparticles with tunable properties.
- Surface functionalization enables site-specific targeting, enhancing therapeutic outcomes.
Conclusions:
- Albumin nanoparticles represent a promising platform for advanced drug delivery systems.
- Continued research into fabrication and targeting strategies will further optimize their clinical utility.
- Their biocompatibility and biodegradability underscore their safety profile for therapeutic use.
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