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Related Experiment Videos

Prevention of malaria.

J S Keystone1

  • 1Tropical Disease Unit, Toronto General Hospital, Ontario, Canada.

Drugs
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Malaria chemoprophylaxis is challenging due to drug resistance and toxicity. Doxycycline and mefloquine are recommended for multidrug-resistant Plasmodium falciparum malaria, but no drug guarantees complete protection.

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Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Increasing chloroquine-resistant Plasmodium falciparum malaria necessitates updated chemoprophylaxis strategies.
  • Concerns exist regarding the efficacy and toxicity of alternative antimalarial drugs.

Purpose of the Study:

  • To review current recommendations for malaria chemoprophylaxis.
  • To evaluate the efficacy and safety of various antimalarial drugs for travelers.

Main Methods:

  • Literature review of studies on malaria chemoprophylaxis.
  • Analysis of drug efficacy, toxicity, and resistance patterns.

Main Results:

  • Amodiaquine is not recommended for chemoprophylaxis due to toxicity.

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  • Pyrimethamine/sulfadoxine is best used for presumptive therapy.
  • Proguanil's efficacy is questionable in some regions, but a proguanil-sulphonamide combination showed efficacy in Thailand.
  • Doxycycline and mefloquine are preferred for multidrug-resistant malaria.

    • Conclusions:

    • Malaria chemoprophylaxis recommendations are complex and evolving.
    • Doxycycline and mefloquine are current drugs of choice for resistant malaria.
    • Travelers must be aware that no antimalarial offers guaranteed protection.