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Posterior fossa ependymomas: a tale of two subtypes
Tenley C Archer1, Scott L Pomeroy
1Department of Neurology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Abstract:
Ependymomas are common childhood brain tumors, but little is known about their underlying biology. In this issue of Cancer Cell, Witt et al. present that posterior fossa ependymomas comprise two distinct molecular subtypes, each with unique gene expression signatures, different levels of genomic instability, and different prognosis.
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