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Updated: May 30, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 15, 2024
Patient-guided peripheral nerve exploration for the management of chronic localized pain
Jason M Souza1, Ake N Nystrom, Gregory A Dumanian
1Chicago, Ill.; and Omaha, Neb. From the Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, and the University of Nebraska Medical Center.
Unlabelled:
This technique represents a surgical adjunct for the management of chronic, localized pain in patients who continue to have pain despite exhaustive prior evaluation and treatment. The patient-guided approach was used in 10 patients referred with "intractable pain" and yielded good to excellent results in all but one patient. When applied selectively to cases with significantly distorted anatomy or previous failed interventions, this simple technique can minimize dissection and unnecessary resection, while offering relief to a patient population otherwise resigned to a life with chronic pain.
Clinical Question/Level Of Evidence:
Therapeutic, V.
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