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Updated: May 30, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue shock syndrome with two atypical complications
Hasmukh Chapsi Gala1, Bhupendra S Avasthi, Madhukar R Lokeshwar
1Department of Pediatrics, Lilavati Hospital and Research Centre, Mumbai, India. drhasmukhgala@hotmail.com
Indian Journal of Pediatrics
|August 16, 2011
Summary
Dengue shock syndrome can cause rare complications like abdominal compartment syndrome and acute demyelinating encephalomyelitis. Prompt interventions, such as paracentesis and steroid therapy, led to recovery in these pediatric cases.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Background:
- Dengue shock syndrome (DSS) is a severe manifestation of dengue virus infection, primarily affecting children.
- While DSS commonly presents with plasma leakage and circulatory failure, unusual complications can arise, posing diagnostic and therapeutic challenges.
Observation:
- Case 1: A 14-year-old boy with DSS developed abdominal compartment syndrome (ACS) requiring aggressive fluid resuscitation, leading to shock, increased ventilator needs, and oliguria.
- Case 2: An 8-year-old girl with DSS and acute respiratory distress syndrome (ARDS) developed severe neurological complications, including seizures and altered sensorium, in the second week of illness.
Findings:
- Abdominal paracentesis in Case 1 successfully relieved ACS, draining 2.7 liters of fluid and resulting in rapid recovery.
- CT brain findings in Case 2 indicated acute demyelinating encephalomyelitis (ADEM), which resolved completely following pulse steroid therapy.
Implications:
- These cases highlight the importance of recognizing and managing uncommon complications of DSS, such as ACS and ADEM.
- Early and appropriate interventions, including paracentesis for ACS and steroid therapy for ADEM, can significantly improve outcomes in severe dengue cases.
- Further research into the pathophysiology and management of rare DSS complications is warranted to optimize patient care.
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