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Glycerin suppository for promoting feeding tolerance in preterm very low birthweight neonates: a randomized

Suvarna Shinde1, Nandkishor S Kabra, Shobha R Sharma

  • 1Department of Neonatology, Surya Childrens Hospital, Santacruz West, Mumbai, India. Correspondence to: Dr Nandkishor S Kabra, Department of Neonatology, Surya Childrens Hospital, Mangal Ashirwad, Junction of S V Road and Dattatraya Road, Santacruz West, Mumbai 400054 India. nskabra@gmail.com.

Indian Pediatrics
|June 24, 2014
PubMed

Insights

Glycerin suppositories did not improve feeding tolerance in preterm very-low-birthweight infants. This study found no significant difference in achieving full enteral feeds with suppository use.

Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Pediatrics

Background:

  • Preterm very-low-birthweight neonates often experience feeding difficulties.
  • Optimizing feeding tolerance is crucial for infant growth and development.

Purpose of the Study:

  • To evaluate the efficacy of daily glycerin suppositories in enhancing feeding tolerance in preterm very-low-birthweight neonates.
  • To compare the time to achieve full enteral feeds between neonates receiving glycerin suppositories and those not receiving them.

Main Methods:

  • A randomized controlled trial was conducted in a Level III neonatal unit.
  • 50 preterm neonates (birth weight 1000-1500g, gestational age 28-32 weeks) were randomized to receive glycerin suppositories or no intervention.
  • The primary outcome was the time required to achieve full enteral feeds (180 mL/kg/d).

Main Results:

  • No significant difference was observed in the mean duration to achieve full enteral feeds between the glycerin suppository group (11.90 days) and the control group (11.33 days).
  • While the glycerin suppository group regained birth weight slightly earlier, the difference was not statistically significant.
  • There were no significant differences in hospital stay duration or the incidence of necrotizing enterocolitis between the groups.

Conclusions:

  • Daily glycerin suppository application does not accelerate the achievement of full enteral feeds in preterm very-low-birthweight neonates.
  • Glycerin suppositories do not appear to improve feeding tolerance or clinical outcomes in this vulnerable population.
Abstract

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