Related Experiment Video

Updated: Feb 7, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.5K

Interventions to Prevent Intraventricular Haemorrhage in Preterm Neonates: An Umbrella Review of Systematic Reviews

Mayuri Bhanushali1, Haribalakrishna Balasubramanian2, Hemant Sharma1

  • 1Department of Neonatology, Surya Children's Hospital, Mumbai, India.

Neonatology
|February 5, 2026
PubMed

Insights

Administering antenatal corticosteroids and magnesium sulfate, along with early lung protective strategies, significantly reduces severe intraventricular hemorrhage (IVH) in preterm infants. Further research on IVH care bundles is recommended.

Area of Science:

  • Neonatal Medicine
  • Perinatal Health
  • Evidence Synthesis

Background:

  • Intraventricular hemorrhage (IVH) is a significant concern in preterm infants.
  • Systematic reviews are crucial for synthesizing evidence on interventions to reduce IVH.
  • Identifying effective perinatal and neonatal interventions is essential for improving preterm infant outcomes.

Purpose of the Study:

  • To provide an overview of systematic reviews evaluating randomized controlled trials (RCTs) of perinatal/neonatal interventions for reducing IVH in preterm infants.
  • To synthesize evidence on the effectiveness of various interventions based on high-quality systematic reviews.
  • To assess the certainty of evidence for interventions aimed at preventing IVH.

Main Methods:

  • Comprehensive search of major databases (PubMed, EMBASE, Cochrane) for systematic reviews and meta-analyses of RCTs.
  • Inclusion of studies on preterm infants or those at risk of preterm birth, focusing on IVH outcomes.
  • Quality assessment of systematic reviews using AMSTAR 2 and certainty of evidence using GRADE recommendations.
  • Meta-analysis of outcome data using the Metaumbrella package in R software.

Main Results:

  • 148 systematic reviews were included, with 118 focusing on postnatal interventions.
  • Antenatal corticosteroids, magnesium sulfate, volume-targeted ventilation, early surfactant administration, and prophylactic indomethacin significantly reduced severe IVH (moderate certainty of evidence).
  • Respiratory function monitors, heated humidified respiratory gases, and early erythropoietin supplementation showed potential benefits (very low certainty of evidence).

Conclusions:

  • Antenatal steroids, magnesium sulfate, and early neonatal lung-protective strategies are effective in reducing IVH rates in preterm neonates.
  • High-quality systematic reviews indicate moderate certainty of evidence for several key interventions.
  • Further adequately powered RCTs are needed to evaluate IVH care bundles with long-term follow-up.
Abstract

Keywords:
Intraventricular haemorrhageMeta-analysisNeonatePretermSystematic review

More Related Videos

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K
Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

3.5K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.5K
Nursing Interventions I: Taxonomy of Nursing Interventions01:03

Nursing Interventions I: Taxonomy of Nursing Interventions

Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
3.9K
Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
3.4K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.1K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K