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Updated: May 30, 2026
07:44
A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
[Acute massive pulmonary thromboembolism with cardiac arrest]
Katsuhiko Matsuyama1, Tomohiro Nakayama, Hiroaki Hagiwara
1Department of Cardiovascular Surgery, Tajimi Hospital, Tajimi, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|August 17, 2011
Summary
Acute massive pulmonary embolism (APE) patients requiring cardiopulmonary resuscitation (CPR) can be successfully treated with pulmonary thrombectomy and percutaneous cardiopulmonary support (PCPS). This approach offers a life-saving option for critically ill APE patients, even after prolonged CPR.
Area of Science:
- Cardiology
- Thoracic Surgery
- Critical Care Medicine
Background:
- Acute massive pulmonary embolism (APE) carries a high mortality rate, particularly in patients requiring cardiopulmonary resuscitation (CPR).
- Patients undergoing CPR for APE often experience severe brain damage or multiple organ failure, complicating treatment and worsening prognosis.
Observation:
- This study reports on four patients with APE transferred from outside hospitals under continuous CPR.
- Three of the four patients required percutaneous cardiopulmonary support (PCPS) for stabilization.
- Despite CPR for up to 40 minutes, none of the patients exhibited pre-operative brain damage.
Findings:
- Successful open pulmonary thrombectomy was performed under on-pump beating cardiopulmonary support in all four patients.
- All patients demonstrated dramatic clinical improvement post-procedure.
- The patients were discharged without any complications.
Implications:
- Rapid CPR, prompt echocardiographic diagnosis, and swift establishment of PCPS are crucial for managing hemodynamically unstable APE patients.
- This strategy highlights the potential for successful surgical intervention in APE patients previously considered high-risk due to cardiac arrest and prolonged CPR.
- Pulmonary thrombectomy combined with PCPS offers a viable and effective treatment option for severe APE, improving survival rates and patient outcomes.
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