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Primary parotid gland lymphoma: a case report
Petros Konofaos1, Eleftherios Spartalis, Paraskevas Katsaronis
1Department of Propedeutic Surgery, 'LAIKO' General Hospital 17, Ag Thomas Street, Athens 11527, Greece. petros_konofaos@yahoo.com
Journal of Medical Case Reports
|August 17, 2011
Summary
A benign lymphoepithelial lesion of the parotid gland transformed into a low-grade mucosa associated lymphoid tissue lymphoma. This rare salivary gland malignancy highlights the importance of considering lymphoma in cystic parotid masses.
Area of Science:
- Oncology
- Pathology
- Otolaryngology
Background:
- Mucosa associated lymphoid tissue (MALT) lymphomas are the most common salivary gland lymphomas.
- Benign lymphoepithelial lesions (BLEL) are lymphoproliferative diseases of the parotid gland.
- MALT lymphoma can arise from a pre-existing BLEL.
Purpose of the Study:
- To report a rare case of BLEL transforming into low-grade MALT lymphoma.
- To emphasize the importance of considering MALT lymphoma in the differential diagnosis of parotid gland lesions.
Main Methods:
- A case report of a 78-year-old female smoker with a three-year history of left facial swelling.
- Surgical resection of the left parotid gland with facial nerve preservation.
- Histopathological analysis confirming low-grade marginal-zone B-cell non-Hodgkin lymphoma (MALT lymphoma) following BLEL.
Main Results:
- The patient was diagnosed with a low-grade MALT lymphoma arising from a BLEL of the parotid gland.
- The lesion presented as a cystic mass in the parotid gland.
Conclusions:
- Salivary gland MALT lymphoma should be considered in the differential diagnosis of cystic or bilateral salivary gland lesions.
- Parotidectomy is recommended for diagnosis and treatment.
- Adjuvant radiotherapy and chemotherapy may be considered for disseminated disease or post-operatively.