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Updated: Aug 7, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Brain tumor as a second malignant neoplasm following neuroblastoma stage IV S

M W Ben-Arush1, Y Doron, J Braun

  • 1Department of Pediatric Oncology, Rambam Medical Center, Technion School of Medicine, Haifa, Israel.

Medical and Pediatric Oncology
|January 1, 1990
PubMed

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...