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Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
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Valproic acid utilizes the isoleucine breakdown pathway for its complete β-oxidation.

Paula B M Luís1, Jos P Ruiter, Rob Ofman

  • 1Research Institute for Medicines and Pharmaceutical Sciences, iMed.UL, University of Lisbon, Lisbon, Portugal.

Biochemical Pharmacology
|August 17, 2011
PubMed
Summary

Valproic acid (VPA) interferes with isoleucine metabolism by inhibiting 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD). This study identifies MHBD and crotonase as key enzymes in VPA beta-oxidation and isoleucine breakdown.

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