Related Experiment Video
Updated: May 30, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Serum unconjugated bisphenol A concentrations in men may influence embryo quality indicators during in vitro
Michael S Bloom1, Frederick S Vom Saal, Dongsul Kim
1Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, USA. mbloom@albany.edu
Abstract:
Here we assess bisphenol A (BPA) in couples undergoing in vitro fertilization (IVF) and indicators of embryo quality; embryo cell number (ECN) and embryo fragmentation score (EFS). Twenty-seven couples provided serum on the day of oocyte retrieval. Unconjugated BPA was measured by HPLC with Coularray detection. Odds ratios (OR) were generated using ordinal logistic regression including female and male BPA concentrations, age and race, and day of embryo transfer for ECN. Inverse associations are suggested for male BPA with ECN (OR=0.70, P=0.069), and EFS (OR=0.54, P=0.009), but not for women. Male BPA exposure may affect embryo quality during IVF.
Related Concept Videos
Oogenesis
Spermatogenesis
Teratogenicity
Infertility in Males
Serum Studies: Renal Function Tests

