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IL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responses

Rita Vasconcellos1, Natalie A Carter, Elizabeth C Rosser

  • 1Centre for Rheumatology Research, University College London, London WC1E 6JF, United Kingdom.

Journal of Immunology (Baltimore, Md. : 1950)
|August 17, 2011
PubMed
Summary

Mice lacking the IL-12p35 subunit showed milder Ag-induced arthritis due to increased IL-27 and IL-10, promoting regulatory T and B cells. Neutralizing IL-27 reversed this protective effect, highlighting IL-12p35 as an IL-27 response regulator.

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