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Related Experiment Video

Updated: May 30, 2026

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

Published on: March 20, 2018

Electron microscopy at a sub-50 pm resolution.

K Takayanagi¹, S Kim, S Lee

¹Physics Department, Tokyo Institute of Technology, Japan. takayang@phys.titech.ac.jp

Journal of Electron Microscopy

|August 17, 2011

Summary

This summary is machine-generated.

A new aberration-corrected electron microscope achieves sub-47 picometer resolution, enabling atomic-level imaging of light elements like lithium and 3D visualization of dopant clusters within crystals.

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Last Updated: May 30, 2026

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

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Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy

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Published on: August 15, 2014

Area of Science:

Materials Science
Physics
Chemistry

Background:

Advanced electron microscopy is crucial for understanding materials at the atomic scale.
Imaging light elements and buried structures presents significant challenges.

Purpose of the Study:

To demonstrate the capabilities of a novel aberration-corrected electron microscope.
To achieve atomic resolution imaging of light elements and buried dopant clusters.

Main Methods:

Utilized an aberration-corrected scanning transmission electron microscope (STEM) with a cold-field emission gun at 300 kV.
Employed sub-50 picometer STEM for high-depth resolution imaging.

Main Results:

Experimentally achieved a resolution better than 47 picometers.
Successfully imaged individual lithium atoms.
Demonstrated three-dimensional imaging of dopant clusters within crystals.

Conclusions:

The developed electron microscope offers unprecedented resolution for atomic-scale materials analysis.
Enables detailed characterization of light elements and buried nanostructures.