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[Age-specific reference ranges for prostate specific antigen in 16 222 Chinese men]
Meng Guan1, Shuo-lei Sun, Ri-hua Xie
1Department of Urology, McGill University, Montreal H9X 3V9, Canada.
Summary
This study found the mean prostate-specific antigen (PSA) level for Chinese men is 0.986 μg/L, with a 95% percentile of 2.375 μg/L. Age-specific reference values differ from global standards, suggesting tailored screening for Chinese populations.
Area of Science:
- Urology
- Biochemistry
- Public Health
Background:
- Prostate-specific antigen (PSA) is a key biomarker for prostate health.
- Establishing population-specific reference ranges is crucial for accurate diagnostic interpretation.
- Existing PSA reference values are largely based on Western populations.
Purpose of the Study:
- To determine the normal prostate-specific antigen (PSA) levels in a large cohort of asymptomatic Chinese men.
- To investigate age-related variations in PSA levels within this population.
- To compare Chinese PSA levels with established international reference values.
Main Methods:
- Serum samples were collected from 16,222 asymptomatic men undergoing health examinations.
- Prostate-specific antigen (PSA) levels were measured using MEIA with an ILMA instrument.
- Data were analyzed to determine mean, standard deviation, and percentiles, stratified by age.
Main Results:
- The mean PSA level was 0.986 μg/L, with a 95% percentile of 2.375 μg/L.
- Significant differences in PSA levels were observed across various age groups.
- Chinese men under 60 had lower PSA levels than Euramericans, while those over 60 had higher levels.
Conclusions:
- The established mean PSA level for Chinese men is 0.986 μg/L, with a 95% percentile of 2.375 μg/L.
- Current international PSA reference values may not be directly applicable to the Chinese population.
- Recommended PSA reference values should be adjusted based on age, with 2.5 μg/L for men under 60 and 4 μg/L for men over 60.
