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Cholestatic hepatitis with intravenous ceftriaxone
Inderpal Kaur1, Jatinder Singh
1Department of Surgery, Government Medical College, Amritsar, Punjab, India.
Indian Journal of Pharmacology
|August 17, 2011
Summary
Drug-induced liver injury can cause acute hepatitis or cholestasis. This report details a case of cholestatic hepatitis resulting from intravenous ceftriaxone, a common antibiotic.
Area of Science:
- Hepatology
- Pharmacology
- Internal Medicine
Background:
- Drug-induced liver injury (DILI) is a significant global health concern.
- Hepatitis, cholestasis, and mixed patterns are common DILI presentations.
- Ceftriaxone, a third-generation cephalosporin, is frequently used postoperatively.
Purpose of the Study:
- To report a case of cholestatic hepatitis linked to intravenous ceftriaxone administration.
- To contribute to the understanding of ceftriaxone-associated liver injury.
Main Methods:
- Case report detailing clinical presentation, laboratory findings, and treatment.
- Review of existing literature on ceftriaxone and DILI.
Main Results:
- The patient developed cholestatic hepatitis following intravenous ceftriaxone.
- Liver enzyme levels indicated a cholestatic pattern.
Conclusions:
- Intravenous ceftriaxone can induce cholestatic hepatitis.
- Clinicians should consider ceftriaxone as a potential cause of liver injury in susceptible patients.
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