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Updated: May 30, 2026

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Click approaches to functional water-sensitive organotriethoxysilanes
Kristýna Bürglová1, Nirmalya Moitra, Jana Hodačová
1Institut Charles Gerhardt Montpellier (UMR 5253 CNRS-UM2-ENSCM-UM1), 8, rue de l'École Normale, 34296 Montpellier, France.
Abstract:
The derivatization of functional organic fragments with triethoxysilyl groups to afford hydrolyzable organosilanes with targeted properties using the copper-catalyzed alkyne azide cycloaddition reaction under strictly anhydrous conditions is described according to two approaches, starting from five silylated substrates. This high yield, fast, and selective method is applicable to a wide range of substrates and is expected to lead to important achievements in the field of functional hybrid silica.
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