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Updated: May 30, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
[Preparation and study of a new type substrate for Raman enhancement]
Yong-Jun Wu1, Kun Dong, Chao Feng
1Institute of Advanced Materials for Photoelectronics, Kunming University of Science and Technology, Kunming 650051, China. aukss@163.com
Abstract:
A highly ordered anodic aluminum oxide template was prepared, the mixture of phosphate and chromic acid was used to remove the oxide layer, regular pits array on the surface of the aluminum was obtained, then AC electrodeposit method was used to get fluffy nano silver structure, which was tested with SEM. Melamine was chosen as the probe molecule, the Raman peaks of melamine with 10(-12) g x mL(-1) were successfully detected, and the molecule number of the melamine is about 3.8 x 10(-6) at this concentration and laser spot through calculation, which is beyond the detection level of monolayer. The enhancement factor reached 1.41 x 10(11).
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