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Related Experiment Videos

Adverse drug effects.

P P Lamy1

  • 1Center for the Study of Pharmacy and Therapeutics for the Elderly, University of Maryland, School of Pharmacy, Baltimore.

Clinics in Geriatric Medicine
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Elderly individuals experience more adverse drug effects due to age-related changes and polypharmacy. Patient, caregiver, or provider errors significantly contribute to adverse drug events.

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Area of Science:

  • Gerontology
  • Clinical Pharmacology
  • Patient Safety

Background:

  • Adverse drug effects disproportionately impact the elderly population compared to younger individuals.
  • Age-related physiological changes affect how the body processes and responds to medications (pharmacokinetics and pharmacodynamics).
  • High daily medication counts (polypharmacy) are a primary contributor to increased adverse drug effects in older adults.

Purpose of the Study:

  • To elucidate the factors contributing to the higher incidence of adverse drug effects in the elderly.
  • To differentiate between adverse drug reactions and adverse drug events.
  • To identify the role of medication errors in adverse drug events.

Main Methods:

  • Review of existing literature on geriatric pharmacokinetics, pharmacodynamics, and polypharmacy.

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  • Analysis of factors contributing to adverse drug reactions in elderly populations.
  • Examination of the definition and causes of adverse drug events, including medication errors.

    • Main Results:

    • Age-related pharmacokinetic and pharmacodynamic alterations increase susceptibility to adverse drug effects in the elderly.
    • Polypharmacy is a major driver of adverse drug effects in older patients.
    • Medication errors by patients, caregivers, or healthcare providers are significant contributors to adverse drug events.

    Conclusions:

    • The elderly are at increased risk for adverse drug effects due to physiological changes and polypharmacy.
    • Expanding the scope to adverse drug events highlights the critical role of medication errors in patient safety.
    • Interventions targeting polypharmacy and reducing medication errors are crucial for improving geriatric patient safety.