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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
Update in Human Immunodeficiency Virus and Aging
Jason R Faulhaber1, Anthony W Baffoe-Bonnie1, Krisann K Oursler2
1Virginia Tech Carilion School of Medicine, Carilion Clinic, Division of Infectious Diseases, 213 McClanahan St SW, Roanoke, VA 24014, USA.
People with human immunodeficiency virus (HIV) experience accelerated aging due to complex factors, increasing their risk for age-related diseases. Enhanced vigilance and interventions are crucial for their care.
Area of Science:
- Gerontology
- Immunology
- Pharmacology
Background:
- Effective antiretroviral therapy (ART) has increased lifespan for people with HIV (PWH).
- PWH now face age-related health conditions similar to the general aging population.
- The aging process in PWH is distinct and potentially accelerated compared to HIV-negative individuals.
Purpose of the Study:
- To explore the unique aging process in PWH.
- To identify factors contributing to accelerated aging in PWH.
- To highlight the need for tailored clinical interventions.
Main Methods:
- This study synthesizes current research on aging in PWH.
- It examines molecular, microbiologic, and pharmacologic factors.
- It reviews clinical outcomes and comorbidities associated with aging in PWH.
Main Results:
- Aging in PWH is characterized by accelerated biological processes.
- Key contributing factors include chronic inflammation, viral persistence, and ART side effects.
- PWH exhibit a higher prevalence of age-related comorbidities.
Conclusions:
- The aging process in PWH is significantly influenced by HIV and its treatment.
- Accelerated aging necessitates specialized monitoring and proactive management strategies.
- Increased clinical vigilance and tailored interventions are essential for PWH care.
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