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Updated: May 30, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
Published on: March 17, 2023
Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine
Elizabeth Ratcliffe1, Robert J Thomas, David J Williams
1Centre for Biological Engineering, Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, LE11 3TU, UK. e.ratcliffe@lboro.ac.uk
Background:
A novel manufacturing industry is emerging to translate unique cellular therapy bioprocesses to robust, scaled manufacturing production for successful clinical translation.
Source Of Data:
This review summarizes key translational issues, and current and future perspectives to improve translation of cell-based therapy bioprocessing, based on literature search and author research.
Areas Of Agreement:
It is widely recognized that cell-based therapies could revolutionize health care for a range of diseases, and that there are gaps in the overarching framework and technologies to generate clinical success.
Areas Of Controversy:
There is limited understanding of how to fulfil requirements as regulatory and manufacturing guidelines are incomplete and few have achieved commercialization.
Growing Points:
Recent developments are encouraging adoption of automation and quality engineering approaches for bioprocessing of cell-based therapies.
Areas Timely For Developing Research:
Include technology development to improve the cost and purity of manufacture and final product quality.
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