Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypertension IV: Drug Therapy and Lifestyle Modifications

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...

Hypertension V: Nursing Management

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Hypertension I: Introduction

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...

Heart Failure V: Medical Management

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bolus Dosing of Alteplase in Hemodynamically Unstable Acute Pulmonary Embolism.

The Annals of pharmacotherapy·2024

Same author

Oral Anticancer Therapy: Management of Drug Interactions.

Journal of oncology practice·2019

Same author

Improving pharmacist knowledge of oral chemotherapy in the community.

The Annals of pharmacotherapy·2012

Same author

Efaproxiral: a radiation enhancer used in brain metastases from breast cancer.

The Annals of pharmacotherapy·2005

Search research articles

Related Experiment Video

Updated: May 30, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Treating hypertension in the very elderly.

Margaret M Charpentier¹, Andrew Bundeff

¹Department of Pharmacy Practice, University of Rhode Island, Kingston, RI, USA. chaps@uri.edu

The Annals of Pharmacotherapy

|August 20, 2011

Summary

Managing blood pressure in patients 80 and older requires careful consideration. While lowering blood pressure (BP) can reduce stroke risk, it may increase mortality in the very elderly.

Area of Science:

Gerontology
Cardiology
Clinical Pharmacology

Background:

Hypertension management guidelines, such as the Seventh Report of the Joint National Committee (JNC 7), recommend a blood pressure (BP) goal of less than 140/90 mm Hg for all adults.
The very elderly population (80 years and older) presents unique challenges for BP management due to potential risks like falls and adverse drug interactions.

Purpose of the Study:

To review the existing evidence regarding the efficacy and safety of strict blood pressure management in individuals aged 80 years and older.
To evaluate current guidelines and physician practices for treating hypertension in the very elderly.

Main Methods:

A comprehensive literature search was conducted using PubMed and the Cochrane Database, focusing on studies published from 1950 through November 2010.

Related Experiment Videos

Last Updated: May 30, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Searches included MeSH terms for hypertension and the elderly, along with broader searches for recent publications and referenced primary literature.

Main Results:

Evidence indicates that while lowering BP reduces stroke risk, it may be associated with increased mortality in the very elderly.
Randomized controlled trials and meta-analyses show reductions in stroke, heart failure, and cardiovascular events in this age group.
Recent guidelines suggest a cautious approach with potentially different BP targets for the very elderly.

Conclusions:

Optimal hypertension management in the very elderly remains an area of concern with limited conclusive studies.
The Hypertension in the Very Elderly Trial (HYVET) provided significant mortality findings but left questions about ideal BP targets.
Further research is needed to establish definitive BP management strategies for patients aged 80 and above.