Related Experiment Video
Updated: May 30, 2026
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
Longitudinal study of macular folds by spectral-domain optical coherence tomography
1Vitreoretinal Service, Guy's and St. Thomas' Hospital National Health Service Foundation Trust, Ophthalmology Department, St. Thomas' Hospital, London, United Kingdom. roger.wong@gstt.nhs.uk
Purpose:
To understand the natural history of macular folds using serial spectral-domain optical coherence tomography (SD-OCT).
Design:
Prospective case series.
Method:
Serial OCTs were performed using Topcon 3D OCT. The main outcome measures were: patient demographics; preoperative, perioperative, and postoperative details; serial SD-OCTs; and length of follow-up.
Results:
Ten patients who underwent standard 3-port pars plana vitrectomy with gas tamponade to repair rhegmatogenous retinal detachment were included in this study. Mean follow-up was 9.9 months (range 5-17 months). Three types of retinal folds were identified: 1) ripple; 2) taco; 3) displacement. Ripple and taco folds were found to resolve spontaneously. Outer retinal hyperreflective lesions resolved first, followed by flattening of the inner retinal layers. Displacement folds also resolved, but left the macula translocated inferiorly, causing binocular diplopia.
Conclusion:
Ripple and taco folds could be managed conservatively with good outcomes. However, the optimal treatment of displacement folds requires further research.
