Related Experiment Video

Updated: May 30, 2026

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
08:30

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

Published on: September 6, 2024

Psychiatric features in children with genetic syndromes: toward functional phenotypes

Matthew S Siegel1, Wendy E Smith

  • 1Department of Psychiatry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02110, USA. siegem@springharbor.org

Pediatric Clinics of North America
|August 23, 2011
PubMed

Insights

Genetic neurodevelopmental disorders offer insights into gene-brain-behavior links. Understanding common genetic conditions and their treatments aids child psychiatrists in managing diverse patient populations with developmental delays.

Area of Science:

  • Child psychiatry
  • Neurodevelopmental disorders
  • Genetics

Background:

  • Genetic etiologies in neurodevelopmental disorders provide a model for studying gene-brain-behavior relationships.
  • Children with developmental delay have a higher prevalence of mental illness.
  • Familiarity with common genetic disorders is crucial for practitioners serving general child populations.

Purpose of the Study:

  • To review basic genetic testing.
  • To discuss 11 common genetic disorders associated with neurodevelopmental conditions.
  • To present the evidence base for treatment of these disorders.

Main Methods:

  • Review of genetic testing procedures.
  • Compilation of information on 11 prevalent genetic disorders.
  • Synthesis of treatment evidence for each disorder.

Main Results:

  • Overview of genetic testing in child psychiatry.
  • Detailed review of 11 common genetic disorders.
  • Summary of current treatment evidence for these conditions.

Conclusions:

  • Child psychiatrists, with expertise in development and multimodal treatment, are well-suited to integrate various phenotypes.
  • Focusing on functional impairment is key when addressing complex presentations in children with genetic disorders.
  • Understanding genetic conditions improves care for children with developmental delays and associated mental health issues.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane07:38

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...