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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Published on: December 19, 2019

Cutaneous paraneoplasia.

Marcia Ramos-E-Silva1, Joana Castro Carvalho, Sueli Coelho Carneiro

  • 1Sector of Dermatology and Post Graduation Course of Dermatology, University Hospital Clementino Fraga Filho andSchool of Medicine, Federal University of Rio de Janeiro, 22280-020 Rio de Janeiro, Brazil. ramos.e.silva@dermato.med.br

Clinics in Dermatology
|August 23, 2011
PubMed
Summary
This summary is machine-generated.

Paraneoplastic syndromes, skin manifestations of cancer, require prompt dermatologic recognition. Early diagnosis of these rare conditions, like acanthosis nigricans, improves cancer prognosis.

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Area of Science:

  • Dermatology
  • Oncology
  • Internal Medicine

Background:

  • Paraneoplastic syndromes often precede malignant tumor detection.
  • Recognition by dermatologists is crucial for early cancer diagnosis and improved patient outcomes.
  • These cutaneous manifestations are relatively rare but diagnostically significant.

Purpose of the Study:

  • To detail the morphologic aspects of key paraneoplastic syndromes.
  • To outline the differential diagnosis for these skin conditions.
  • To enhance dermatologists' familiarity with identifying and diagnosing paraneoplastic syndromes for earlier cancer detection.

Main Methods:

  • Review of morphologic characteristics of common paraneoplastic syndromes.
  • Discussion of differential diagnostic considerations.
  • Compilation of key clinical features for identification.

Main Results:

  • Detailed descriptions of acanthosis nigricans, tripe palms, Leser-Trélat sign, acquired ichthyosis, acquired hypertrichosis lanuginosa, pityriasis rotunda, erythema gyratum repens, palmo-plantar keratoderma, Bazex syndrome, and dermatomyositis.
  • Emphasis on the link between these dermatologic findings and underlying malignancies.
  • Highlighting diagnostic criteria for each condition.

Conclusions:

  • Paraneoplastic syndromes serve as vital early indicators of underlying cancers.
  • Familiarity with their diverse presentations aids dermatologists in timely diagnosis.
  • Early identification significantly impacts cancer prognosis and patient management.