Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topical sucralfate in the management of peristomal skin disease: an open study.

Clinical and experimental dermatology·2001
Same author

The bio-availability of fluoride from black tea.

Journal of dentistry·2001
Same author

Quality use of medicines in the community: the Australian experience.

British journal of clinical pharmacology·2001
Same author

Genomic organization and comparative analysis of the mouse tuberous sclerosis 1 (Tsc1) locus.

Mammalian genome : official journal of the International Mammalian Genome Society·2000
Same author

The spectrum of skin disorders in abdominal stoma patients.

The British journal of dermatology·2000
Same author

Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive.

The Journal of physiology·2000
Same journal

Prognostic and diagnostic evaluation of HSPG2 gene expression in oral squamous cell carcinoma: A case-control study.

Archives of oral biology·2026
Same journal

Dental traits: From anthropological foundations to clinical implications.

Archives of oral biology·2026
Same journal

Surface properties of irradiated and non-irradiated dentin following pH cycling and fluoride toothpaste exposure: An in vitro study.

Archives of oral biology·2026
Same journal

CircSSRP1 regulates SMAD3 to affect proliferation and apoptosis of human embryonic palatal mesenchymal cells in nonsyndromic cleft lip with or without cleft palate by sponging miR-708-5p.

Archives of oral biology·2026
Same journal

Development of models of preclinical stage 2 bisphosphonate-related osteonecrosis of the jaw in non-rodent mammals using zoledronate: A systematic review.

Archives of oral biology·2026
Same journal

Impact of lifestyle factors on salivary nitrite and nitrate concentrations in overweight/obese individuals.

Archives of oral biology·2026
See all related articles

Related Experiment Video

Updated: May 30, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Dentine as a bioactive extracellular matrix.

A J Smith1, B A Scheven, Y Takahashi

  • 1School of Dentistry, University of Birmingham, Birmingham, UK. a.j.smith@bham.ac.uk

Archives of Oral Biology
|August 23, 2011
PubMed
Summary
This summary is machine-generated.

Dentine, a tooth component, possesses regenerative potential despite being considered inert. Bioactive molecules within dentine matrix offer new therapeutic avenues for tissue repair.

More Related Videos

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

Related Experiment Videos

Last Updated: May 30, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

Area of Science:

  • Biomaterials Science
  • Dental Research
  • Tissue Engineering

Background:

  • Dentine is a mineralized connective tissue crucial for tooth structure.
  • Traditionally viewed as inert, dentine-pulp exhibits significant regenerative capacity.
  • Cell-matrix interactions and disease processes influence dentine's response to injury.

Purpose of the Study:

  • To explore the regenerative potential of dentine-pulp.
  • To understand the role of cell-matrix interactions in dentine's response to injury.
  • To identify bioactive molecules within dentine for novel therapeutic applications.

Main Methods:

  • Review of existing literature on dentine biology and regenerative potential.
  • Analysis of cell-matrix interactions in dentine-pulp complex.
  • Identification and characterization of bioactive molecules within the dentine matrix.

Main Results:

  • Dentine-pulp complex demonstrates robust regenerative potential following injury.
  • Bioactive molecules are present within the dentine matrix.
  • Cell-matrix interactions significantly modulate tissue responses.

Conclusions:

  • Dentine is not inert and possesses inherent regenerative capabilities.
  • Bioactive molecules in dentine matrix present opportunities for new clinical therapies.
  • Understanding dentine's regenerative mechanisms can advance dental tissue engineering.