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Updated: Aug 9, 2026
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
The pathobiology of ozone-induced damage
J J Steinberg1, J L Gleeson, D Gil
1Department of Pathology, Albert Einstein College of Medicine, Bronx, New York.
Archives of Environmental Health
|March 1, 1990
Summary
Ozone exposure causes DNA damage and depresses DNA replication, indicating genotoxicity. This review explores how ozone affects DNA, potentially impacting gene expression and cellular processes.
Area of Science:
- Environmental Health
- Molecular Biology
- Toxicology
Background:
- Ozone is a major air pollutant with poorly understood genotoxic effects.
- Ozone exposure causes oxidative stress, leading to DNA damage.
- Tissue damage occurs in airways and alveoli, but cellular mechanisms are unclear.
Purpose of the Study:
- To review the genotoxicity of ozone exposure.
- To explore the molecular mechanisms of ozone-induced DNA damage.
- To discuss the implications of DNA alterations on gene expression and cellular function.
Main Methods:
- Literature review of studies on ozone exposure and DNA damage.
- Analysis of ozone's effects on DNA replication and structure.
- Examination of ozone-induced DNA adducts and their consequences.
Main Results:
- Ozone depresses DNA replication in lung fibroblasts in a dose-dependent manner.
- Ozone can linearize circular DNA and trigger DNA repair mechanisms.
- DNA adducts formed by ozone are linked to aging, mutagenesis, and carcinogenesis.
Conclusions:
- Ozone exhibits genotoxic potential through direct DNA interaction and oxidative stress.
- Ozone-induced DNA alterations may affect gene transcription and cellular regulation.
- Further research is needed to fully understand ozone's impact on cellular and molecular processes.
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