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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...

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Related Experiment Video

Updated: May 30, 2026

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

Extracorporeal lung perfusion.

Marcelo Cypel1, Shaf Keshavjee

  • 1Division Thoracic Surgery, University of Toronto, 200 Elizabeth St, Toronto, Canada.

Current Opinion in Organ Transplantation
|August 23, 2011
PubMed
Summary
This summary is machine-generated.

Ex-vivo lung perfusion (EVLP) offers a promising solution to the donor lung shortage by allowing assessment and repair of organs before transplantation. This technique improves lung utilization and outcomes in lung transplant recipients.

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Related Experiment Videos

Last Updated: May 30, 2026

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
05:49

Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation

Published on: September 29, 2023

Area of Science:

  • Transplantation immunology
  • Cardiothoracic surgery
  • Organ preservation technologies

Background:

  • Lung transplantation faces organ shortages due to donor limitations and donor lung injury.
  • Low utilization rates of donor lungs stem from injuries during brain death and intensive care unit (ICU) care.

Purpose of the Study:

  • To evaluate ex-vivo lung perfusion (EVLP) as a method to increase donor lung utilization.
  • To assess the safety and efficacy of EVLP in improving the function of injured donor lungs.

Main Methods:

  • Ex-vivo lung perfusion (EVLP) was employed to maintain donor lungs under physiological conditions.
  • A clinical trial was conducted to assess EVLP-treated lungs.
  • Preclinical studies explored EVLP as a platform for therapeutic interventions.

Main Results:

  • The first clinical trial demonstrated EVLP to be safe, enabling reassessment and functional improvement of high-risk donor lungs.
  • Transplantation of EVLP-treated lungs resulted in low rates of primary graft dysfunction.
  • Early outcomes after EVLP lung transplantation were comparable to conventional methods.

Conclusions:

  • EVLP represents a significant advancement in lung transplantation, potentially increasing organ availability and quality.
  • Experimental and clinical evidence supports the safety and broad potential of EVLP.
  • EVLP serves as a platform for novel therapies to repair donor lungs ex vivo.