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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...

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Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

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Published on: September 20, 2024

Pediatric epilepsy and psychopathology.

Monisha Goyal1

  • 1Rainbow Babies and Children`s Hospital, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Avenue, M/S 6090, Cleveland, Ohio 44106-6090, United States of America. Tel. +1 (216) 8443691. Fax. +1 (216) 8448966.

Neurosciences (Riyadh, Saudi Arabia)
|August 23, 2011
PubMed
Summary

Pediatric epilepsy frequently co-occurs with behavioral disorders like autism and ADHD, which can be more disabling than seizures. This review highlights these under-recognized psychiatric comorbidities in children with epilepsy.

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Area of Science:

  • Child neurology
  • Child psychiatry
  • Developmental neuroscience

Background:

  • The link between psychiatric disorders and pediatric epilepsy is often overlooked by healthcare providers.
  • Behavioral issues in children with epilepsy are sometimes incorrectly attributed to reactions to the condition rather than primary comorbidities.
  • These co-occurring psychiatric conditions can significantly impair a child's quality of life, potentially more than epilepsy itself.

Purpose of the Study:

  • To review the prevalence and impact of common behavioral comorbidities in pediatric epilepsy.
  • To increase clinician awareness of the significant association between psychiatric disorders and childhood epilepsy.
  • To discuss specific conditions such as autistic spectrum disorders, psychosis, ADHD, and mood disorders in this population.

Main Methods:

  • Literature review of studies examining psychiatric comorbidities in pediatric epilepsy.
  • Synthesis of findings on the presentation and impact of behavioral disorders in children with epilepsy.
  • Identification of common co-occurring conditions and their clinical significance.

Main Results:

  • Psychiatric disorders are common in children with epilepsy and are frequently underestimated.
  • Conditions like autistic spectrum disorders, attention deficit hyperactivity disorders, psychosis, and mood disorders are significant comorbidities.
  • These behavioral comorbidities can be more debilitating than the epilepsy itself, impacting overall functioning and well-being.

Conclusions:

  • Clinicians must recognize and address the high prevalence of psychiatric comorbidities in pediatric epilepsy.
  • Early identification and management of behavioral disorders are crucial for improving outcomes in children with epilepsy.
  • A comprehensive approach integrating epilepsy and mental health care is essential for affected children.