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Related Concept Videos

SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not observed.
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Long-patch Base Excision Repair

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Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

SERS from two-tier sphere segment void substrates.

Robert P Johnson1, Sumeet Mahajan, Mamdouh E Abdelsalam

  • 1School of Chemistry, University of Southampton, Highfield, Southampton, UK.

Physical Chemistry Chemical Physics : PCCP
|August 23, 2011
PubMed
Summary
This summary is machine-generated.

Gold films with sphere segment voids show promise for surface-enhanced Raman spectroscopy (SERS). Researchers found that single-layer void substrates provide the best SERS enhancements, offering reliable and reproducible results for this sensitive technique.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Spectroscopy

Background:

  • Sphere segment void (inverse opal) films made from coinage metals are effective substrates for surface-enhanced Raman spectroscopy (SERS).
  • These substrates are fabricated using colloidal templates of polystyrene spheres.

Purpose of the Study:

  • To investigate the reflection spectra and SERS performance of gold films with two-tiered spherical cavities.
  • To determine the optimal configuration of sphere segment void substrates for SERS applications.

Main Methods:

  • Fabrication of gold films with varying layers of sphere segment voids using colloidal templates.
  • Characterization of film reflection spectra.
  • Evaluation of SERS enhancement factors using the fabricated substrates.

Main Results:

  • Gold films with sphere segment voids exhibit tunable optical properties.
  • The highest SERS enhancements were achieved with substrates featuring a single layer of sphere segment voids.
  • Substrates with multiple tiers of voids did not yield superior SERS performance compared to single-layer designs.

Conclusions:

  • Single-layer sphere segment void gold films are optimal for achieving maximum SERS enhancement.
  • The findings provide guidance for the design of efficient SERS substrates.
  • This research contributes to the development of reliable and reproducible SERS platforms.