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Melatonin: can it stop the ringing?

Agnes Hurtuk¹, Claudia Dome, Christopher H Holloman

¹Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA.

The Annals of Otology, Rhinology, and Laryngology

|August 24, 2011

Summary

This summary is machine-generated.

Oral melatonin significantly reduces tinnitus severity and improves sleep quality in chronic tinnitus patients. It is most effective for men, those without prior depression, and individuals with severe, bilateral tinnitus or noise exposure history.

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Area of Science:

Otolaryngology
Neurotology
Sleep Medicine

Background:

Chronic tinnitus affects a significant portion of the population, often leading to sleep disturbances and decreased quality of life.
Current treatment options for chronic tinnitus have limited efficacy, necessitating the exploration of alternative therapeutic agents.

Purpose of the Study:

To evaluate the efficacy of oral melatonin as a treatment for chronic tinnitus.
To identify specific patient subgroups that may experience greater benefits from melatonin therapy.

Main Methods:

A prospective, randomized, double-blind, crossover clinical trial was conducted.
Adults with chronic tinnitus received either 3 mg melatonin or placebo nightly for 30 days, followed by a 1-month washout period and crossover.
Standardized assessments including Tinnitus Matching (TM), Tinnitus Severity Index (TSI), Self Rated Tinnitus (SRT), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were used.

Main Results:

Melatonin treatment resulted in a statistically significant decrease in tinnitus matching (TM) and self-rated tinnitus (SRT) scores compared to placebo (p < 0.05).
Positive responses to melatonin were associated with male gender, bilateral tinnitus, noise exposure history, no prior tinnitus treatment, absence of baseline depression/anxiety, and higher pretreatment TSI scores.
Absence of depression/anxiety, higher pretreatment TSI, and higher pretreatment SRT scores predicted greater improvement in both tinnitus and sleep with melatonin.

Conclusions:

Oral melatonin is an effective treatment for chronic tinnitus, leading to significant reductions in tinnitus intensity and improvements in sleep quality.
Melatonin demonstrates particular efficacy in male patients, those without a history of depression, individuals with severe or bilateral tinnitus, and those with a history of noise exposure.