Related Experiment Video

Updated: May 30, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Apical hypertrophic cardiomyopathy

Syed Wamique Yusuf1, Jaya D Bathina, Jose Banchs

  • 1Syed Wamique Yusuf, Jaya D Bathina, Jose Banchs, Elie N Mouhayar, Iyad N Daher, Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.

World Journal of Cardiology
|August 24, 2011
PubMed

Insights

Apical hypertrophic cardiomyopathy (AHCM) can be asymptomatic but may lead to cardiac arrhythmias. Early diagnosis via echocardiography and advanced imaging, alongside appropriate medical or device therapy, is crucial for managing this rare condition.

Area of Science:

  • Cardiology
  • Genetics

Background:

  • Apical hypertrophic cardiomyopathy (AHCM) is a rare variant of hypertrophic cardiomyopathy affecting the left ventricular apex.
  • It can present asymptomatically or with diverse cardiac symptoms including arrhythmias and heart failure.

Purpose of the Study:

  • To describe a case of asymptomatic AHCM progressing to cardiac arrhythmias.
  • To review diagnostic modalities, differential diagnoses, and treatment options for AHCM.

Main Methods:

  • Case report of a patient with AHCM.
  • Review of diagnostic tools: electrocardiogram (ECG), transthoracic echocardiogram (TTE), cardiac MRI, CT, and left ventriculography.
  • Discussion of pharmacologic and device-based treatments.

Main Results:

  • The patient initially asymptomatic, later developed cardiac arrhythmias.
  • Classic ECG findings include giant negative T-waves and left ventricular hypertrophy.
  • TTE is the initial diagnostic tool, revealing apical hypertrophy; advanced imaging aids in differential diagnosis.

Conclusions:

  • AHCM diagnosis requires a combination of clinical presentation and imaging.
  • Management involves risk stratification and tailored therapy, including medications and potentially an implantable cardioverter-defibrillator for high-risk individuals.

Keywords:
Apical hypertrophic cardiomyopathyElectrocardiogram

More Related Videos

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...