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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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Reduction of metastasis using a non-volatile buffer.

Arig Ibrahim Hashim1, Heather H Cornnell, Maria de Lourdes Coelho Ribeiro

  • 1Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA. arig.ibrahimhashim@moffitt.org

Clinical & Experimental Metastasis
|August 24, 2011
PubMed
Summary
This summary is machine-generated.

Oral buffering agents like 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA) can reduce cancer metastasis. This study shows IEPA, a non-volatile buffer, effectively lowers tumor acidity and inhibits cancer spread in mice.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Biochemistry

Background:

  • Tumor microenvironment acidity promotes cancer invasion and metastasis.
  • Sodium bicarbonate has previously shown potential in reducing metastasis by increasing tumor pH.
  • The mechanism of bicarbonate's effect, whether buffering or via carbonic anhydrase, required further investigation.

Purpose of the Study:

  • To investigate the efficacy of a non-volatile buffer, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), in reducing cancer metastasis.
  • To determine if the anti-metastatic effect is due to pH buffering per se.
  • To confirm the oral availability and tumor pH-altering effects of IEPA.

Main Methods:

  • Utilized a PC3M prostate cancer mouse model with luciferase-expressing cells.
  • Administered 200 mM IEPA in drinking water to experimental groups prior to tumor cell inoculation.
  • Monitored metastasis using in vivo imaging and measured tumor pH.
  • Confirmed IEPA presence and oral availability using in vivo magnetic resonance spectroscopy.

Main Results:

  • IEPA treatment significantly reduced experimental lung metastasis in mice (P < 0.04).
  • Tumor pH was elevated in IEPA-treated animals compared to controls.
  • In vivo magnetic resonance spectroscopy confirmed IEPA's oral availability and presence in the bladder.

Conclusions:

  • Non-volatile buffers, such as IEPA, can effectively reduce cancer metastasis.
  • The results suggest that the anti-metastatic effect is mediated by pH buffering within the tumor microenvironment.
  • IEPA represents a potential therapeutic strategy for mitigating cancer spread.