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Related Experiment Video

Updated: May 30, 2026

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

Negative and nonemotional interference with visual working memory in schizophrenia.

Alan Anticevic1, Grega Repovs, Philip R Corlett

  • 1Department of Psychology, Washington University, St. Louis, Missouri, USA. alan.anticevic@yale.edu

Biological Psychiatry
|August 25, 2011
PubMed
Summary
This summary is machine-generated.

Individuals with schizophrenia (SCZ) struggle to filter distractions, unlike healthy controls. This general deficit in filtering interference, not specific to emotional content, impacts visual working memory (WM).

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Schizophrenia (SCZ) is linked to working memory (WM) and emotional processing deficits.
  • Individuals with SCZ may have impaired distraction filtering, potentially worsened by emotional stimuli.
  • Previous research has not used fMRI to examine SCZ effects on visual WM distraction.

Purpose of the Study:

  • To investigate if SCZ involves a general filtering deficit or a specific deficit in filtering emotional distraction.
  • To characterize the effects of negative and non-emotional interference on visual WM in SCZ using fMRI.

Main Methods:

  • fMRI at 3-T was used to image 28 SCZ patients and 24 controls.
  • Subjects performed a visual WM task with negative, neutral, or task-related interference.
  • Blood-oxygen-level-dependent (BOLD) imaging measured brain activity during the task.

Main Results:

  • Controls showed maximal interference from aversive distraction; SCZ patients were distracted by all interference types.
  • SCZ patients exhibited reduced BOLD activity in prefrontal filtering regions after any distraction.
  • SCZ patients showed aberrant responses to non-emotional distraction in posterior cortical regions.

Conclusions:

  • SCZ patients appear to lack the distracter filtering activity seen in controls.
  • Results suggest a general deficit in filtering distraction in SCZ, potentially linked to aberrant salience processing.
  • SCZ is associated with both similar responses to aversive interference and enhanced responses to non-emotional inputs.