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Cushing Syndrome II: Pathophysiology

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

Esophageal Strictures-II: Clinical Features and Management

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Chronic Bowel Disorders: Introduction

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Gastritis II: Pathophysiology

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Barrett Esophagus-II: Clinical Manifestations and Management

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Gastritis-II: Pathophysiology

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Updated: May 30, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Churg-strauss syndrome: an update.

¹Mayo College of Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA. abril.andy@mayo.edu

Current Rheumatology Reports

|August 25, 2011

Summary

Churg-Strauss syndrome, an antineutrophil cytoplasmic antibody-associated vasculitis, is characterized by asthma and eosinophilia. Recent advances in its understanding and treatment are reviewed.

Area of Science:

Rheumatology
Immunology
Pathology

Background:

Churg-Strauss syndrome (CSS) is an uncommon vasculitis, initially misclassified but now recognized as antineutrophil cytoplasmic antibody-associated vasculitis (AAV).
CSS is distinguished by adult-onset asthma, allergic symptoms, and eosinophilia, aiding clinical differentiation from other small vessel vasculitides.

Purpose of the Study:

To review recent advances in the pathophysiology and treatment of Churg-Strauss syndrome.
To highlight key diagnostic features and recent classifications of CSS.

Main Methods:

Literature review of recent studies on Churg-Strauss syndrome.
Analysis of pathological, clinical, and laboratory features of CSS.
Examination of diagnostic criteria and treatment strategies.

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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

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Main Results:

Churg-Strauss syndrome is definitively classified as an antineutrophil cytoplasmic antibody-associated vasculitis.
Two distinct clinical subtypes based on ANCA presence have been identified.
Specific clinical and laboratory findings, including asthma and eosinophilia, are crucial for diagnosis.

Conclusions:

Understanding the pathophysiology and recent treatment advancements is crucial for managing Churg-Strauss syndrome.
Accurate classification and recognition of CSS subtypes improve patient care.
Early identification based on characteristic symptoms is vital for effective intervention.