Related Experiment Video
Updated: May 30, 2026

ODELAY: A Large-scale Method for Multi-parameter Quantification of Yeast Growth
Published on: July 3, 2017
Yeast systems biology: the challenge of eukaryotic complexity
Juan I Castrillo1, Stephen G Oliver
1Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB21GA, UK. jic28@cam.ac.uk
Abstract:
In this chapter, we present an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote for systems biology studies, with main molecular mechanisms, biological networks, and sub-cellular organization essentially conserved in all eukaryotes, derived from a complex common ancestor. The existence of advanced tools for molecular studies together with high-throughput experimental and computational methods, most of them being implemented and validated in yeast, with new ones being developed, is opening the way to the characterization of the core modular architecture and complex networks essential to all eukaryotes. Selected examples of the latest discoveries in eukaryote complexity and systems biology studies using yeast as a reference model and their applications in biotechnology and medicine are presented.
Related Concept Videos
Yeast Signaling
Bioreactor Controls-III
Prokaryotic vs. Eukaryotic Cells
Microbial Morphologies
Eukaryotic Evolution
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Evolutionary Processes in Microbes

