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Measuring continuous baseline covariate imbalances in clinical trial data

Jody D Ciolino1, Reneé H Martin2, Wenle Zhao2

  • 1Division of Biostatistics and Epidemiology, 135 Cannon Street, Suite 303, Medical University of South Carolina, Charleston, SC, USA. jodycio@gmail.com.

Statistical Methods in Medical Research
|August 26, 2011
PubMed
Summary

This study evaluates methods for measuring continuous baseline covariate imbalance in clinical trials. Simulations show the t-test statistic effectively captures imbalance, and covariate-adjusted analysis (ANCOVA) improves hypothesis testing.

Keywords:
baselineclinical trialcovariateimbalance

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