Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental congenital obstructive uropathy.

C A Peters1, J Mandell

  • 1Department of Surgery, Children's Hospital, Boston, Massachusetts.

The Urologic Clinics of North America
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic excision and ureteroureterostomy of blind-ending ureteral 'Duplication'.

Journal of pediatric urology·2018
Same author

Report on The Society for Fetal Urology panel discussion on the selection criteria and intervention for fetal bladder outlet obstruction.

Journal of pediatric urology·2017
Same author

Reoperative robotic pyeloplasty in children.

Journal of pediatric urology·2016
Same author

Changes in the pore network structure of Hanford sediment after reaction with caustic tank wastes.

Journal of contaminant hydrology·2012
Same author

Semiempirical thermodynamic modeling of liquid-liquid phase equilibria: coal tar dissolution in water-miscible solvents.

Environmental science & technology·2011
Same author

B cell infiltration and lymphonodular hyperplasia in bladder submucosa of patients with persistent bacteriuria and recurrent urinary tract infections.

The Journal of urology·2011
Same journal

An Unprecedented Era of Innovation in Non-Muscle-Invasive Bladder Cancer.

The Urologic clinics of North America·2026
Same journal

Hubert Humphrey's Bladder Cancer: If He Could Have Time Traveled, Would that Have Changed the Outcome?

The Urologic clinics of North America·2026
Same journal

Key Clinical Trials Shaping the Future of Superficial High-Risk Bladder Cancer Management.

The Urologic clinics of North America·2026
Same journal

Future Directions: Artificial Intelligence and Digital Tools in Bladder Cancer Care.

The Urologic clinics of North America·2026
Same journal

Economic Considerations in the Management of Superficial Bladder Cancer.

The Urologic clinics of North America·2026
Same journal

Patient-Centered Approaches to Non-Muscle-Invasive Bladder Cancer Care.

The Urologic clinics of North America·2026
See all related articles

Experimental models suggest prenatal intervention benefits severe congenital obstructive uropathy. Further research is needed to confirm efficacy and understand pulmonary and systemic effects for fetal medicine advancements.

Area of Science:

  • Fetal Medicine
  • Pediatric Urology
  • Experimental Surgery

Background:

  • Congenital obstructive uropathy (COU) requires ongoing research to advance fetal medicine.
  • Clinically relevant obstructive lesions can be replicated in experimental models.
  • Limited human data exists on prenatal interventions for COU.

Purpose of the Study:

  • To evaluate the potential benefits of in utero intervention for severe COU with oligohydramnios.
  • To highlight the need for improved understanding of COU's pathophysiology.
  • To identify determinants for functional salvageability of kidneys and lungs in COU.

Main Methods:

  • Development of experimental models to reproduce obstructive uropathy.
  • Analysis of data from these models to inform clinical hypotheses.

Related Experiment Videos

  • Review of limited human experience with prenatal interventions.

    • Main Results:

    • Experimental models suggest in utero intervention may be beneficial in severe COU with oligohydramnios.
    • Human experience demonstrates the technical feasibility of prenatal interventions.
    • Significant gaps remain in understanding the renal, pulmonary, and systemic effects of COU.

    Conclusions:

    • Experimental data tentatively supports in utero intervention for severe COU.
    • Further research is critical to confirm efficacy and understand broader impacts.
    • Resolving indicators for kidney and lung salvageability is a key future direction.