Related Experiment Video

Updated: May 29, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Functional characterization of the complement receptor type 1 and its circulating ligands in patients with

Arsen Arakelyan1, Roksana Zakharyan, Aren Khoyetsyan

  • 1Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, 7 Hasratyan St,, 0014, Yerevan, Armenia. aboyajyan@sci.am.

BMC Clinical Pathology
|August 27, 2011
PubMed

Insights

Schizophrenia is linked to higher levels of C1q-complement-containing immune complexes (C1q-CIC) and increased complement receptor type 1 (CR1) expression on blood cells, particularly erythrocytes. These findings suggest a role for CR1 and C1q-CIC in schizophrenia pathogenesis.

Area of Science:

  • Immunology
  • Neuroscience
  • Genetics

Background:

  • Complement system alterations are implicated in schizophrenia.
  • Complement receptors and regulators remain understudied in schizophrenia.
  • Complement receptor type 1 (CR1) plays a role in immune regulation.

Purpose of the Study:

  • Investigate CR1 expression on blood cells in schizophrenia patients.
  • Quantify circulating immune complexes (CIC) involving CR1 ligands (C1q, C3d).
  • Analyze the functional CR1 C5507G polymorphism in relation to schizophrenia.

Main Methods:

  • Compared CR1 expression on erythrocytes, lymphocytes, and monocytes between schizophrenia patients and controls.
  • Measured levels of C1q-CIC and C3d-CIC.
  • Genotyped the CR1 C5507G polymorphism.

Main Results:

  • Schizophrenia patients exhibited increased C1q-CIC levels and elevated CR1 expression on blood cells.
  • A higher number of CR1-positive erythrocytes and fewer CR1-positive lymphocytes/monocytes were observed in patients.
  • No significant difference in C3d-CIC levels was found between groups.
  • The CC genotype of CR1 C5507G was associated with higher CR1 expression on erythrocytes.

Conclusions:

  • Schizophrenia is associated with increased CR1 expression and elevated C1q-CIC levels.
  • These findings highlight a potential role for CR1 and C1q-CIC in schizophrenia.
  • Further research in diverse ethnic groups is recommended for validation.
Abstract

More Related Videos

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...