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Naives, nonresponders, relapsers: who is there left to treat?

Archita P Desai1, Nancy Reau

  • 1Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA.

Clinics in Liver Disease
|August 27, 2011
PubMed

Insights

Hepatitis C virus (HCV) poses a significant health challenge in the US. New therapies and improved screening are crucial to reduce HCV

Area of Science:

  • Hepatology and Viral Gastroenterology
  • Public Health and Epidemiology
  • Clinical Trial Design and Therapeutics

Background:

  • Hepatitis C virus (HCV) infection is highly prevalent in the United States.
  • The disease burden of HCV is projected to increase significantly over the next 20-30 years.
  • Current treatment strategies require optimization to effectively manage HCV.

Purpose of the Study:

  • To highlight the need for clinical trials evaluating novel HCV therapies.
  • To emphasize the importance of optimizing existing triple drug regimens for HCV control.
  • To advocate for improved treatment uptake and expanded screening for chronic hepatitis C.

Main Methods:

  • Review of current epidemiological data on Hepatitis C prevalence and disease burden.
  • Analysis of advancements in antiviral agents, including telaprevir and boceprevir.
  • Discussion on strategies to enhance treatment accessibility and screening protocols.

Main Results:

  • Improvements in achieving sustained virologic response (SVR) with new agents have been observed.
  • Telaprevir and boceprevir demonstrate potential in managing HCV.
  • Enhanced treatment uptake and screening are critical for disease control.

Conclusions:

  • Successful control of Hepatitis C necessitates further research into new therapies.
  • Optimizing triple drug therapies and increasing treatment rates are essential.
  • Re-evaluating universal or inclusive screening for chronic HCV is warranted to lower morbidity and mortality.

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