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Updated: May 29, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Mixing and matching drugs: what makes sense?
Tania M Welzel1, Stefan Zeuzem
1Department of Medicine 1, JW Goethe University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt a.M., Germany.
Abstract:
The introduction and ongoing development of directly acting antiviral agents (DAAs) and drugs targeting host cell structures will change the management of patients with chronic hepatitis C virus (HCV) infection. The concomitant use of the protease inhibitors telaprevir or boceprevir with the standard of care, a combination of pegylated interferon (PegIFN) and ribavirin, will represent the new standard for the treatment of HCV genotype 1 infection. Contraindications and side effects limit the applicability of interferon-based therapies and motivate the investigation of PegIFN-sparing regimens. Different DAA combinations under investigation are reviewed in this article.
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