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Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Venous Thrombosis Assay in a Mouse Model of Cancer
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Behçet's Syndrome and Thrombosis.

Emire Seyahi1, Sebahattin Yurdakul

  • 1Department of Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.

Mediterranean Journal of Hematology and Infectious Diseases
|August 27, 2011
PubMed
Summary

Behçet syndrome (BS) is a rare vasculitis affecting multiple systems, often presenting with skin lesions and eye inflammation. Vascular complications, particularly venous thrombosis, are common and a major cause of mortality in BS.

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Behçet syndrome (BS) is a multisystem vasculitis of unknown etiology.
  • It typically manifests in the third decade with recurrent mucocutaneous lesions and panuveitis.
  • Males experience more severe disease than females.

Purpose of the Study:

  • To summarize the key features of Behçet syndrome, focusing on its vascular manifestations.
  • To highlight the diagnostic hallmarks and common complications of BS.
  • To underscore the importance of immunosuppressive treatment.

Main Methods:

  • Review of existing literature on Behçet syndrome.
  • Analysis of clinical presentation, disease course, and pathological findings.
  • Emphasis on vascular involvement patterns and outcomes.

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Main Results:

  • Vascular involvement occurs in up to 40% of BS cases, affecting all vessel types but favoring veins.
  • Common vascular manifestations include lower extremity deep vein thrombosis, vena cava thrombosis, and aneurysms.
  • Neutrophilic vasculitis around vaso vasorum is characteristic; thromboembolism is rare despite high venous disease frequency.

Conclusions:

  • Behçet syndrome is characterized by significant vascular involvement, a primary driver of mortality.
  • Immunosuppressive therapy is crucial for managing BS activity and preventing attacks.
  • Further research into BS etiology and pathogenesis is warranted.