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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

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Irritable bowel syndrome.

Michael A Malone¹

¹Department of Family Medicine, Penn State College of Medicine, 845 Fishburn Road, Hershey, PA 17033, USA. mmalone@hmc.psu.edu

|August 30, 2011

Summary

This summary is machine-generated.

Irritable bowel syndrome (IBS) is a common gastrointestinal condition causing abdominal pain and altered bowel habits. While manageable, IBS has no known cure and does not lead to serious diseases like cancer.

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Area of Science:

Gastroenterology
Internal Medicine

Background:

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder.
It is characterized by abdominal pain, bloating, and changes in bowel habits.
IBS is diagnosed in the absence of identifiable organic pathology.

Purpose of the Study:

To provide a comprehensive overview of Irritable Bowel Syndrome (IBS).
To discuss the classification, symptoms, and patient impact of IBS.
To clarify the non-progressive and non-life-threatening nature of IBS.

Main Methods:

Literature review of IBS pathophysiology and clinical presentation.
Analysis of diagnostic criteria and symptom classification.
Synthesis of information on prognosis and management.

Main Results:

IBS presents with diverse symptoms including crampy pain, gassiness, bloating, and altered bowel habits.
Patients are classified into diarrhea-predominant, constipation-predominant, or mixed subtypes.
IBS is frequently associated with psychological factors like stress and anxiety.

Conclusions:

IBS is a chronic condition that significantly impacts quality of life but does not cause intestinal damage or increase cancer risk.
While treatments can alleviate symptoms, a definitive cure for IBS remains elusive.
Understanding IBS is crucial for effective patient management and reassurance.