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Maternal smoking during pregnancy, polymorphic CYP1A1 and GSTM1, and lung-function measures in urban family children

Xinguang Chen1, Ibrahim Abdulhamid, Kimberley Woodcroft

  • 1The Adams Ann Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA. jimchen@med.wayne.edu

Environmental Research
|August 30, 2011
PubMed

Insights

Maternal smoking during pregnancy significantly impacts child lung development. Specific gene variations, like CYP1A1 and GSTM1, in mothers can worsen these effects on lung function in children.

Area of Science:

  • Environmental Health
  • Pediatric Pulmonology
  • Genetic Epidemiology

Background:

  • Maternal smoking during pregnancy is a known risk factor for adverse child lung development.
  • The specific genetic predispositions that modify the impact of prenatal tobacco exposure on lung function are not fully understood.

Purpose of the Study:

  • To investigate the hypothesis that maternal genetic variations in Cytochrome P450 1A1 (CYP1A1) and Glutathione S-transferase Mu 1 (GSTM1) influence the association between prenatal tobacco exposure and reduced lung function in children.
  • To quantify the impact of maternal smoking on child lung function, considering specific CYP1A1 and GSTM1 genotypes.

Main Methods:

  • A cohort of 370 children (aged 6-10 years) and their biological mothers was studied.
  • Multiple regression analysis was employed to test hypotheses, controlling for relevant covariates.
  • Spirometric measures of lung function (FVC, FEV1, FEV1/FVC ratio, FEF25-75) were assessed in children.

Main Results:

  • Maternal smoking during pregnancy was associated with reduced forced vital capacity (FVC) and FEV1/FVC ratio in children.
  • For children of mothers with the CYP1A1*2A homozygous genotype, daily maternal smoking was linked to significant reductions in FEV1 and FVC.
  • Maternal smoking was also associated with FVC reduction in children whose mothers had the GSTM1 deletion.

Conclusions:

  • Maternal smoking during pregnancy adversely affects lung function in children.
  • The detrimental effects of prenatal tobacco exposure on child lung function are significantly exacerbated in the presence of specific maternal genetic variations, namely CYP1A1*2A and GSTM1 deletion.
Abstract

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